If you are talking about those units that look like tankless water heaters, do your research. Anything above 200,000 BTU is truly considered a "boiler"; anything less is a heater regardless of what they call it. If it's truly a "boiler" (>200,000 BTU) you need a specialized plumber with a boiler license.
I point this out since you have to determine what your heat load will be for the home, as well as what your hot water demands will be. Some families will require enough simultaneous hot water usage such as a 199,900 BTU tankless alone will be needed to reach the desired temp rise and flow rate. If that's the case, there's no room for heat--unless you get a second unit. If you have a second unit, well--why bother with a combo?
My older house (built 1992) had a furnace of 125,000 BTU and a 50 gal water heater that was probably 40,000 BTU. However, there were similar sized homes in my neighborhood that had either a 75 gallon or two 50s for the water to meet family demand...
So, do your calculations before making a decision.