I have done it in a work trailer, with 20 gallon w/h and a small fan coil unit
it will work, but....be advised...a water heater does neat heat the water to a temp that is suitable for heating a room.
what you will get is it will keep it above freezing, 60 degres max..
and, your pump needs to be small, you will need a ball valve on you r return line to throttle the flow way down
install multible ball valves to get the air out.
water heater....water in at the top, out at the bottom, mount pump on the bottom with direction of flow towards w/h
set w/h at max,
i figure a 18 wheeler office trailer, 8x50 is about the same size it was in the mountains in the winter
covered in snow. good luck. post back